Korenblit Lab

Main Research Interests​

Proteostasis is a fragile equilibrium between properly folded proteins and the removal or refolding of improperly folded ones. It is achieved by a complex network of molecular chaperones, the ubiquitin-proteasome system, autophagy systems and protein aggregation. The ability to maintain protein homeostasis is one of the first physiological functions to decline during aging. The failure to prevent and counteract proteotoxicity with age renders old organisms hypersensitive to proteotoxic stress,

and results in age-related diseases.

Our main goal is to find new ways to improve

healthspan and proteostasis.