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Korenblit Lab

Integrated Microfluidic Platform for Longitudinal Imaging, Functional Assays, and Downstream Proteomics in C. elegans

Noa Marchoom-Bura, Shira Zelikman, David Morgenstern, Yishi Levin, Efrat Barbiro-Michaely, Ehud Banin, Sivan Henis-Korenblit, Doron Gerber. Small 2025.

HLH-30/TFEB Rewires the Chaperone Network to Promote Proteostasis Upon Perturbations to the Coenzyme A and Iron-Sulfur Cluster Biosynthesis Pathways

Rewayd Shalash, Dror Michael Solomon, Mor Levi-Ferber, Henrik von Chrzanowski, Mohammad Khaled Atrash, Barak Nakar, Matan Yosef Avivi, Hagit Hauschner, Aviya Swisa, Alicia Melendez, Yaron Shav-Tal, Sivan Henis-Korenblit. Aging Cell 2025.

PemB, a type III secretion effector in Pseudomonas aeruginosa, affects Caenorhabditis elegans life span

Shira Zelikman, Reut Dudkevich, Hadar Korenfeld-Tzemach, Esther Shmidov, Mor Levi-Ferber, Sivan Shoshani, Shay Ben-Aroya, Sivan Henis-Korenblit, Ehud Banin. Heliyon 2024.

Cross-species modeling of muscular dystrophy in Caenorhabditis elegans using patient-derived extracellular vesicles

Rewayd Shalash , Mor Levi-Ferber , Coral Cohen, Amir Dori, Chaya Brodie, Sivan Henis-Korenblit. Dis Model Mech 2024.

Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism

Reut Dudkevich , Jhee Hong Koh , Caroline Beaudoin-Chabot , Cenk Celik , Ilana Lebenthal Loinger , Sarit Karako-Lampert , Syed Ahmad-Albukhari , Guillaume Thibault , Sivan Henis-Korenblit. Cell Reports 2022.

Neuronal regulated ire-1-dependent mRNA decay controls germline differentiation in Caenorhabditis elegans

Mor Levi-Ferber , Rewayd Shalash , Adrien Le-Thomas , Yehuda Salzberg, Maor Shurgi, Jennifer IC Benichou, Avi Ashkenazi, Sivan Henis-Korenblit. eLife 2021.

Inactivation of the Caenorhabditis elegans RNF-5 E3 ligase promotes IRE-1-independent ER functions

Orit Adir, Ulrike Bening-Abu-Shach, Shir Arbib, Sivan Henis-Korenblit, Limor Broday.
Autophagy 2021.

Structural Principles in Robo Activation and Autoinhibition

Reut Barak, Galit Yom-Tov, Julia Guez-Haddad, Lital Gasri-Plotnitsky, Roy Maimon, Moran Cohen-Berkman, Andrew A. McCarthy, Eran Perlson, Sivan Henis-Korenblit, Michail N. Isupov, Yarden Opatowsky. cell 2019.

Methods to determine the role of autophagy proteins in
C. elegans aging

Sivan Henis-Korenblit, Alicia Meléndez. Methods 2019.

Reduced Insulin/Insulin-Like Growth Factor Receptor Signaling Mitigates Defective Dendrite Morphogenesis in Mutants of the ER Stress Sensor IRE-1

Yehuda Salzberg, Andrew J. Coleman, Kevin Celestrin , Moran Cohen-Berkman, Thomas Biederer, Sivan Henis-Korenblit, Hannes E. Bulow. PLOS Genetics 2017.

Transdifferentiation mediated tumor suppression by the endoplasmic reticulum stress sensor IRE-1 in C. elegans

Mor Levi-Ferber, Hai Gian, Reut Dudkevich, Sivan Henis-Korenblit. eLife 2015.

It's All in Your Mind: Determining Germ Cell Fate by Neuronal IRE-1 in C. elegans

Mor Levi-Ferber, Yehuda Salzberg, Modi Safra, Anat Haviv-Chesner, Hannes E. Bülow,
Sivan Henis-Korenblit. PLOS Genetics 2014.

The FOXO Transcription Factor DAF-16 Bypasses ire-1 Requirement to Promote Endoplasmic Reticulum Homeostasis

Modi Safra, Rolf Fickentscher, Mor Levi-Ferber, Yehuda M. Danino, Anat Haviv-Chesner, Malene Hansen, Tamar Juven-Gershon, Matthias Weiss, Sivan Henis-Korenblit. Cell Metabolism 2014.

A new tool in C. elegans reveals changes in secretory protein metabolism in ire-1-deficient animals

Modi Safra, Sivan Henis-Korenblit. Worm 2014.

The ire-1 ER stress-response pathway is required for normal secretory-protein metabolism in C. elegans

Modi Safra, Shani Ben-Hamo, Cynthia Kenyon, Sivan Henis-Korenblit. Journal of Cell Science 2013.

Insulin/IGF-1 signaling mutants reprogram ER-stress response regulators to promote longevity

Sivan Henis-Korenblit, Peichuan Zhang, Malene Hansen, Cynthia Kenyon. PNAS 2010.

A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans

Arjumand Ghazi, Sivan Henis-Korenblit, Cynthia Kenyon. PLOS Genetics 2009.

Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex

Arjumand Ghazi, Sivan Henis-Korenblit, Cynthia Kenyon. PNAS 2007.

Endogenous siRNAs promote proteostasis and longevity in germline-less Caenorhabditis elegans

Moran Cohen-Berkman, Reut Dudkevich, Shani Ben-Hamo, Alla Fishman, Yehuda Salzberg, Hiba Waldman Ben-Asher, Ayelet T Lamm, Sivan Henis-Korenblit. eLife 2020.

Innate immunity mediated longevity and longevity induced by germ cell removal converge on the C-type lectin domain protein IRG-7

Elad Yunger, Modi Safra, Mor Levi-Ferber, Anat Haviv-Chesner, Sivan Henis-Korenblit. PLOS Genetics 2017.

Turning off the Wnt—a dietary restriction switch for healthy aging

Anat Haviv‐Chesner, Sivan Henis‐Korenblit‏. EMBO reports 2019. ‏

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